Novel heterocyclic compounds

Details Novel heterocyclic compounds Novel heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) A61K 31/395 (2006.01) C07D 203/08 (2006.01) C07D 203/10 (2006.01) C07D 207/16 (2006.01) C07D 211/22 (2006.01) C07D 211/52 (2006.01) C07D 211/62 (2006.01) C07D 211/78 (2006.01) C07D 215/48 (2006.01) C07D 217/26 (2006.01) C07D 241/04 (2006.01) C07D 243/08 (2006.01) C07D 265/30 (2006.01) C07D 295/15 (2006.01) C07D 295/205 (2006.01)

Patent

CA 2217194

A compound of formula (1), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to composition containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

La présente invention se rapporte à un composé de formule (I). Z est sélectionné parmi (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) et (k). L'invention concerne de nouveaux acides carboxyliques azahétérocycliques N-substitués et leurs esters, dans lesquels une chaîne alkyle substitutée fait partie du substituant N ou de ses sels, leur procédé de fabrication, des compositions les contenant et leur utilisation pour le traitement clinique d'états douloureux, hyperalgésiques et/ou inflammatoires dans lesquelles les fibres C jouent un rôle pathophysiologique en provoquant une douleur ou inflammation neurogène.

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