Novel heterocyclic compounds

Details Novel heterocyclic compounds Novel heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/395 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2217197

A compound of formula (I) in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), and (k). The present invention relates to novel N- substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Composé de formule (I) dans laquelle Z est sélectionné parmi les groupes (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) et (k). L'invention porte sur de nouveaux acides carboxyliques azahétérocycliques N-substitués et leurs esters, dans lesquels une chaîne alkyle substituée fait une partie des N-substituants ou de leurs sels, sur leurs modes de préparation, sur des compositions les contenant, et sur leur emploi pour le traitement clinique d'états douloureux, hyperalgésiques et/ou inflammatoires dans lesquels les fibres C jouent un rôle pathophysiologique dans l'apparition de douleurs ou d'inflammations neurogènes.

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