Novel heterocyclic compounds and drug compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 263/54 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61K 31/538 (2006.01) A61K 31/553 (2006.01) C07D 263/56 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2355079

Compounds represented by general formula (I) or salts thereof, giving drug compositions particularly suitable for oral administration which are useful in the treatment and prevention of .beta.3-related diseases including diabetes, obesity and hyperlipidemia: in said formula R1 is hydrogen, methyl or SO2R3; R2 is O, S or H2; R2' is O or H2; R3 is lower alkyl or NR4R4'; R4 and R4' are each independently hydrogen, lower alkyl or benzyl; R5 is hydrogen or lower alkyl; k and m are each 0 or 1; and A is a group represented by general formula, (II) or (III): (wherein X1 is secondary nitrogen, oxygen, sulfur or methylene; n is 1 or 2; X2 is secondary nitrogen, oxygen or sulfur; and R6, R7 and R8 are each hydrogen or the like).

L'invention concerne des composés représentés par la formule générale (I), ou des sels de ceux-ci, fournissant des compositions de médicaments convenant pour l'administration orale et utilisées pour le traitement et la prévention de maladies apparentées à .beta.3, comprenant le diabète, l'obésité et l'hyperlipidémie, formule dans laquelle R?1¿ désigne l'hydrogène, un méthyle ou SO¿2?R?3¿; R?2¿ désigne O, S ou H¿2?; R?2'¿ désigne O ou H¿2?; R?3¿ désigne un alkyle inférieur ou NR?4¿R?4'¿; R?4¿ et R?4'¿ désignent chacun, indépendamment, un hydrogène, un alkyle inférieur ou un benzyle; R?5¿ désigne un hydrogène ou un alkyle inférieur; k et m sont égaux, respectivement, à 0 ou 1; et A est un groupe représenté par la formule générale (II) ou (III) (dans lesquelles X¿1? désigne un azote secondaire, l'oxygène ou le soufre; et R?6¿, R?7¿ et R?8¿ désignent chacun un hydrogène ou analogue).

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