Novel heterocyclic compounds as mglu5 antagonists

Details Novel heterocyclic compounds as mglu5 antagonists Novel heterocyclic compounds as mglu5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 13/02 (2006.01) C07D 211/70 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2694359

In Compounds I: Z is a group of the formula, m is 0, 1 or 2; n is 0, 1 or 2; Y is a linking group or is absent; R' is H or OH or is absent; ---- is an optional double bond; and R1, R2 and R3 are selected from a wide range of optionally substituted alkyl, cycloalkyl, aryl and heterocyclic groups. Compounds I are mGlu5 antagonists useful for the treatment of neuromuscular dysfunction of the lower urinary tract, migraine and gastroesophagael reflux disease in mammals. Preferred Compounds I are those having the formula

L'invention concerne des composés de formule (I) dans laquelle formule Z est un groupe de formule, m vaut 0, 1 ou 2 ; n vaut 0, 1 ou 2 ; Y est un groupe de liaison ou est absent ; R' est H ou OH ou est absent ; ---- est une double liaison éventuelle ; et R1, R2 et R3 sont chacun sélectionnés parmi une large palette de groupes alkyles, cycloalkyles, aryles et hétérocycliques éventuellement substitués. Les composés (I) sont des antagonistes du mGlu5 utiles pour le traitement d'un dysfonctionnement neuromusculaire du bas appareil urinaire, de la migraine et d'une maladie de reflux gastro-sophagien chez des mammifères. Les composés (I) préférés sont ceux répondant à la formule

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