C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/343 (2006.01) A61K 31/38 (2006.01) A61K 31/407 (2006.01) A61P 29/00 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2591438
The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.
La présente invention concerne de nouveaux inhibiteurs de la phosphodiestérase de type 4 (PDE4) de formule (1) ainsi que des analogues, des tautomères, des énantiomères, des diastéromères, des régioisomères, des stéréoisomères, des polymorphes, des sels pharmaceutiquement acceptables, des N-oxydes appropriés et des solvates pharmaceutiquement acceptables de ces composés. L'invention concerne également des compositions pharmaceutiques les contenant, ces compositions étant utiles dans le traitement de maladies allergiques et inflammatoires telles que l'asthme, la bronchite chronique, la dermatite atopique, l'urticaire, la rhinite allergique, la conjonctivite allergique, la conjonctivite printanière, le granulome éosinophilique, le psoriasis, l'arthrite rhumatoïde, le choc septique, la rectocolite hémorragique, la maladie de Crohn, la lésion de reperfusion du myocarde et la lésion de reperfusion du cerveau, la glomérulonéphrite chronique, le choc endotoxique et le syndrome de détresse respiratoire de l'adulte.
Gharat Laxmikant Atmaram
Gopalan Balasubramanian
Khairatkar-Joshi Neelima
Auerbach Jonathan N.
Glenmark Pharmaceuticals S.a.
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