C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/4427 (2006.01) A61P 29/00 (2006.01) C07D 307/91 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2522023
The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1), their analogs, their tautomers, their enantiomers, their diasteromers, their regioisomers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxide, their pharmaceutically acceptable solvates and the pharmaceutical compositions containing them. The groups X, Ar, Y, P and R1-R4 are defined in claim 1.
La présente invention concerne de nouveaux composés hétérocycliques, leurs analogues, leurs tautomères, leurs régioisomères, leurs stéréoisomères, leurs énantiomères, leurs diastéréomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs N-oxydes appropriés, leurs solvates pharmaceutiquement acceptables et leurs compositions pharmaceutiques les contenant. La présente invention concerne plus particulièrement de nouveaux inhibiteurs de la phosphodiestérase de type 4 (PDE4) répondant à la formule (1), leurs analogues, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs régioisomères, leurs stéréoisomères, leurs polymorphes, leurs sels pharmaceutiquement acceptables, leurs N-oxydes appropriés, leurs solvates pharmaceutiquement acceptables et les compositions pharmaceutiques les contenant. Les groupes X, Ar, Y, P et R¿1?-R¿4? sont tels que définis dans la revendication 1.
Gharat Laxmikant Atmaram
Gopalan Balasubramanian
Karaunakaran Usha
Lakdawala Aftab Dawoodbhai
Auerbach Jonathan N.
Glenmark Pharmaceuticals S.a.
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