Novel heterocyclic derivatives having indoline, indole or...

C - Chemistry – Metallurgy – 07 – D

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C07D 215/40 (2006.01) A61K 31/404 (2006.01) A61K 31/47 (2006.01) A61K 31/675 (2006.01) A61P 9/10 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01) C07F 9/572 (2006.01) C07F 9/60 (2006.01)

Patent

CA 2233842

A heterocyclic derivative of the formula (I) (see formula I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.

La présente invention concerne des dérivés hétérocycliques représentés par la formule générale (I) suivante ou certains de leurs sels pharmaceutiquement acceptables. Dans cette formule, chaque symbole est tel que défini dans le descriptif. Les composés (I) ou leurs sels pharmaceutiquement acceptables font preuve d'une excellente activité inhibitrice de l'ACAT et de la peroxydation des lipides chez les mammifères. Ils conviennent donc particulièrement comme inhibiteurs de l'ACAT et de la peroxydation des lipides. En l'occurrence, ils conviennent à la prévention et au traitement de l'artériosclérose, de l'hyperlipémie, des lésions artérioscléreuses associées au diabète, et des affections ischémiques du cerveau et du coeur, par exemple.

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