C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/435 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)
Patent
CA 2305342
This invention relates to a series of substituted 3-oxo-pyrrolo[1,2- <u>a</u>]imidazopyridine derivatives of formula (I) where X1-X4, R1, R2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA- A receptor and display anxiolytic and anticonvulsant activity in animal models.
Cette invention concerne un ensemble de dérivés de 3-oxo-pyrrolo[1,2-<u>a</u>]imidazopyridine substitués représentés par la formule (I), dans laquelle X¿1?-X¿4?, R¿1?, R¿2? et Ar sont définis dans la description. En outre, l'invention concerne des compositions pharmaceutiques les contenant et des intermédiaires utilisés dans leur production. Les composés de l'invention sont des ligands du site benzodiazépine sur le récepteur GABA-A et présentent une activité anxiolytique et anticonvulsivante chez des cobayes animaux.
Maryanoff Bruce E.
Mccomsey David
Mcnally James J.
Nortey Samuel O.
Reitz Allen B.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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