Novel heterocyclic nf-kb inhibitors

Details Novel heterocyclic nf-kb inhibitors Novel heterocyclic nf-kb inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) C07D 417/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2646223

The present invention relates to compounds of the general formula (Ih) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, (Ih) wherein A is NR2, S or O; R3a is H, OH, SH, NH2, -C(NR7)NR7'R8, -(CH2)paryl, -(CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, alkoxy, alkylamino, hydroxyalkylamino, halogen, aryl, or heteroaryl; R3 is H, -C(0)NRaRb, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NR4' OR5', NH2, hydroxyalkylamino, alkylamino, alkoxy, cycloalkyl, hetero- cycloalkyl, hydroxyalkyl, or haloalkyloxy; X is NR2', O, or S; Z is N or CR2'.

L'invention concerne des composés de formule générale (Ih) ou des sels pharmaceutiquement acceptables de ceux-ci associés à un acide ou à une base, ou des promédicaments pharmaceutiquement acceptables de ceux-ci ou un stéréoisomère de ceux-ci. Dans la formule (Ih), A désigne NR2, S ou O; R3a désigne H, OH, SH, NH2, -C(NR7)NR7'R8, -(CH2)paryle, -(CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, alkyle, cycloalkyle, hydroxyalkyle, haloalkyle, haloalkyloxy, alkoxy, alkylamine, hydroxyalkylamine, halogène, aryle, ou hétéroaryle; R3 désigne H, -C(0)NRaRb, halogène, alkyle, haloalkyle, aryle, hétéroaryle, OH, SH, NR4' OR5', NH2, hydroxyalkylamine, alkylamine, alkoxy, cycloalkyle, hétéro- cycloalkyle, hydroxyalkyle, ou haloalkyloxy; X désigne NR2', O, ou S; Z désigne N ou CR2'.

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