Novel heterocyclic nf-kb inhibitors

Details Novel heterocyclic nf-kb inhibitors Novel heterocyclic nf-kb inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 211/62 (2006.01) C07D 263/48 (2006.01) C07D 277/56 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2580725

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein R1 is independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R2 is independently -NR3R4, (II) or (III) R3 is independently alkyl, cycloalkyl, alkoxy, alkylamine, -OH, -SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R4 is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R5 is independently H, COR6, C02R6, SOR6, SO2R6, SO3R6, alkyl, cycloalkyl, alkoxy, -NH2, alkylamine, - NR7COR6, halogen, -OH, -SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; R6 is independently H, alkyl, cycloalkyl, -NH2, alkylamine, aryl or heteroaryl; R7 is independently H, alkyl, cycloalkyl, alkoxy, -OH, -SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or l; q is 0, or 1; X is CO, or SO2.

La présente invention concerne des composés de formule générale (I) et des sels et dérivés physiologiquement fonctionnels de ceux-ci, (I), dans laquelle R1 est indépendamment un hydrogène, un alkyle, un cycloalkyle, un hydroxyalkyle, un haloalkyle, un haloalkyloxy, un aryle, un aryle substitué, un hétéroaryle, un hétéroaryle substitué, un arylalkyle ou un arylalkyle substitué ; R2 est indépendamment -NR3R4, (II) ou (III) R3 est indépendamment un alkyle, un cycloalkyle, un alcoxy, un alkylamino, -OH, -SH, un alkylthio, un hydroxyalkyle, un haloalkyle, un haloalkyloxy, un aryle ou un hétéroaryle, R4 est indépendamment un alkyle, un cycloalkyle, un alcoxy, un alkylamino, un alkylthio, un hydroxyalkyle, un haloalkyle, un haloalkyloxy, un aryle ou un hétéroaryle ; R5est indépendamment H, COR6, CO2R6, SOR6, SO2R6, SO3R6, un alkyle, un cycloalkyle, un alcoxy, -NH2, un alkylamino, -NR7COR6, un halogène, -OH, -SH, un alkylthio, un hydroxyalkyle, un haloalkyle, un haloalkyloxy, un aryle ou un hétéroaryle ; R6 est indépendamment H, un alkyle, un cycloalkyle, -NH2, un alkylamino, un aryle ou un hétéroaryle ; R7 est indépendamment H, un alkyle, un cycloalkyle, un alcoxy, -OH, -SH, un alkylthio, un hydroxyalkyle, un aryle ou un hétéroaryle ; p est 0 ou 1 ; q est 0 ou 1 ; X est CO ou SO2.

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