Novel heterocyclic nf-kb inhibitors

Details Novel heterocyclic nf-kb inhibitors Novel heterocyclic nf-kb inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/02 (2006.01) A61K 31/425 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 277/20 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2617225

The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, Formula (III) wherein R3 is H, -C(O)NRaRb, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NR4~ OR5~ , NH2, amine, alkylamine, alkoxy, cycloalkyl, heterocyclo- alkyl,hydroxyalkyl, or haloalkyloxy; R4 is H, halogen, alkyl, -C(NR7)NR7~R8, - (CH2)paryl, -(CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl; R5 is halogen, alkyl, -C(NR7)NR7~R8, -(CH2)paryl, - (CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl.

L'invention concerne des composés de la formule générale (III) ou de leurs sels pharmaceutiquement acceptables et un acide ou une base, ou des promédicaments pharmaceutiquement acceptables ou un stéréoisomère de ceux-ci, dans laquelle R3 représente H, -C(O)NRaRb, halogène, alkyle, haloalkyle, aryle, hétéroaryle, OH, SH, NR4' OR5', NH2, amine, alkylamine, alcoxy, cycloalkyle, hétérocycloalkyle, hydroxyalkyle, ou haloalkyloxy; R4 représente H, halogène, alkyle, -C(NR7)NR7'R8, -(CH2)paryle, -(CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, cycloalkyle, hétérocycloalkyle, haloalkyle, hydroxyalkyle, hydroxyalkylamino, alkylamino, hétéroaryle, ou aryle; R5 représente halogène, alkyle, -C(NR7)NR7'R8, -(CH2)paryle, -(CH2)PNR7R8, -C(O)NR7R8, -N=CR7R8, -NR7C(O)R8, cycloalkyle, hétérocycloalkyle, haloalkyle, hydroxyalkyle, hydroxyalkylamino, alkylamino, hétéroaryle, ou aryle.

Affiliated with

Also associated with

Rating

Novel heterocyclic nf-kb inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel heterocyclic nf-kb inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel heterocyclic nf-kb inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2077909