Novel heterocyclic substituted pyrrolidine amide derivatives

Details Novel heterocyclic substituted pyrrolidine amide derivatives Novel heterocyclic substituted pyrrolidine amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/445 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2275527

The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

L'invention concerne de nouveaux amides dérivés de la pyrrolidine, à substituant hétérocyclique, ayant la formule (1), leurs stéréoisomères et leurs sels acceptables sur le plan pharmaceutique, ainsi que l'utilisation de ces composés en tant qu'antagonistes des récepteurs de la tachykinine. Ces antagonistes sont utiles pour le traitement de maladies et de troubles associés à la tachykinine, en particulier l'asthme, la toux et les bronchites.

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