Novel histone deacetylase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/56 (2006.01) C07C 237/40 (2006.01) C07C 259/10 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2702536

Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.

La présente invention a pour objet de nouveaux composés analogues du stilbène de la formule générale (I), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, hydrates, métabolites, promédicaments, solvates, sels pharmaceutiquement acceptables et leurs compositions. Ces composés peuvent inhiber les HDAC (histone désacétylases) et sont utiles en tant qu'agent thérapeutique ou d'amélioration pour des maladies qui sont impliquées dans la croissance cellulaire telles que les tumeurs malignes, les maladies auto-immunes, les maladies cutanées, les infections, les inflammations, etc.

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