C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2156622
DNA encoding a novel human .beta.2 integrin .alpha. subunit polypeptide, designated .alpha.d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which include extracellular .alpha.d protein fragments, .alpha.d I domain fragments or full length .alpha.d polypeptides and human immunoglobulin constant regions. Binding molecules specific for .alpha.d are also disclosed as useful for modulating the biological activities of .alpha.d. DNA from other species which show homology to human .alpha.d encoding sequences are also disclosed.
L'invention concerne de l'ADN codant une nouvelle sous-unité .beta.¿2? humaine polypeptidique d'intégrine alpha, appelée .alpha.¿d?, ainsi que ses procédés et matières de production par des techniques de recombinaison. L'invention concerne également des protéines de fusion comprenant des fragments protéiques extracellulaires d'.alpha.¿d?, des fragments du domaine I d'.alpha.¿d? ou des polypeptides d'.alpha.¿d? de longueur totale, ainsi que des régions constantes d'immunoglobuline humaine. L'invention concerne en outre des molécules de liaison spécifiques à .alpha.¿d?, utiles pour moduler les activités biologiques d'.alpha.¿d?. Enfin, l'invention concerne de l'ADN tiré d'autres espèces présentant une homologie avec des séquences humaines codant l'.alpha.¿d?.
Gallatin W. Michael
Van Der Vieren Monica
Icos Corporation
Smart & Biggar
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