C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2379580
The present invention is directed to novel human DNA sequences encoding calcium sensitive potassium channel subunits .beta.2, .beta.3a, .beta.3b, .beta.3c, and .beta.3d, the proteins encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of calcium sensitive potassium channels containing human .beta.2, .beta.3a, .beta.3b, .beta.3c, or .beta.3d subunits and inhibitors and agonists of .beta.3 gene transcription.
La présente invention concerne de nouvelles séquences d'ADN humain codant des sous-unités .beta.2, .beta.3a, .beta.3b, .beta.3c, et .beta.3d du canal potassique sensible au calcium. L'invention concerne également les protéines codées par ces séquences d'ADN, des vecteurs comprenant ces séquences d'ADN, des cellules hôtes contenant ces vecteurs, et des méthodes pour identifier des inhibiteurs et des agonistes de canaux potassiques sensibles au calcium contenant des sous-unités .beta.2, .beta.3a, .beta.3b, .beta.3c, ou .beta.3d humaines, et des inhibiteurs et agonistes de la transcription du gène .beta.3.
Lagrutta Armando
Liu Yuan
Swanson Richard
Uebele Victor
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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