C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2222722
In accordance with the present invention, there are provided isolated nucleic acids encoding a human netrin, a human ATPase binding cassette transporter, a human ribosomal L3 subtype, and a human augmenter of liver regeneration as well as isolated protein products encoded thereby. The present invention provides nucleic acid probes that hybridize to invention nucleic acids as well as isolated nucleic acids comprising unique gene sequences located on chromosome 16. Further provided are vectors containing invention nucleic acids, host cells transformed therewith, as well as transgenic non-human mammals that express invention polypeptides. The present invention includes antisense oligonucleotides, antibodies and compositions containing same. Additionally, the invention provides methods for identifying compounds that bind to invention polypeptides.
La présente invention se rapporte à des acides nucléiques isolés codant une nétrine humaine, un transporteur humain de cassette liant l'ATPase, un sous-type humain ribosomique L3 et un promoteur humain de la régénération du foie ainsi que des produits protéiniques isolés qui sont codés par ces acides nucléiques. L'invention se rapporte également à des sondes d'acide nucléique qui s'hybrident aux acides nucléiques de l'invention ainsi que des acides nucléiques isolés comprenant des séquences de gènes uniques situées sur le chromosome 16. En outre, l'invention décrit des vecteurs contenant des acides nucléiques de l'invention, des cellules hôtes transformés par ceux-ci, ainsi que des mammifères transgéniques non humains exprimant les polypeptides de l'invention. L'invention concerne également des oligonucléotides anti-sens, des anticorps, et des compositions les contenant. De plus, l'invention décrit des procédés permettant d'identifier les composés qui se lient aux polypeptides de l'invention.
Burn Timothy C.
Connors Timothy D.
Dackowski William R.
Klinger Katherine W.
Landes Gregory M.
Borden Ladner Gervais Llp
Genzyme Corporation
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