C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/563 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2405078
This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
L'invention concerne des gènes identifiés à partir du chromosome humain 20p13-12 qui sont associés à diverses maladies, y compris l'asthme. L'invention concerne également des séquences nucléotidiques de ces gènes, des acides nucléiques isolés comprenant ces séquences nucléotidiques, et des polypeptides ou des peptides isolés codés par ces séquences. L'invention concerne en outre des vecteurs et des cellules hôtes comprenant les séquences nucléotidiques ou des fragments de celles-ci, ainsi que des anticorps qui se fixent aux polypeptides ou peptides codés. Des ligands qui modulent l'activité des gènes ou des produits géniques décrits sont également concernés. L'invention a également trait à des procédés impliquant l'utilisation des acides nucléiques, polypeptides ou peptides, anticorps et/ou ligands décrits, ainsi que des compositions les contenant, respectivement à mettre en oeuvre ou à utiliser pour le diagnostic ou le traitement de l'asthme ou d'autres maladies.
Allen Kristina
Del Mastro Richard
Dupuis Josee
Keith Tim
Little Randall
Genome Therapeutics Corporation
Macrae & Co.
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