C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/14 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2450129
The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
La présente invention concerne la découverte nouvelle des histones déacétylases humaines (HDAC), dénommées également polypeptides de type histone déacétylase. Cette invention concerne aussi les séquences polynucléotidiques et les polypeptides codés de ces nouvelles HDAC ainsi que des vecteurs comprenant ces polynucléotides et des cellules hôtes comprenant ces vecteurs. Cette invention concerne encore des anticorps qui se lient aux polypeptides HDAC découverts et des techniques utilisant ces anticorps. Cette invention concerne aussi des technique de criblage de modulateurs, tels que des inhibiteurs, des antagonistes ou des agonistes. Cette invention concerne aussi des applications diagnostiques et thérapeutiques qui utilisent ces polynucléotides et ces polypeptides HDAC, ces anticorps et ces modulateurs HDAC. Ces applications conviennent pour des maladies et des pathologies associées à la croissance ou à la prolifération anormale des cellules, à la différentiation cellulaire et à la survie cellulaire, par exemple la croissance de cellules néoplasiques et en particulier les cancers ou les tumeurs de la prostate et du sein.
Attar Ricardo M.
Gottardis Marco
Jackson Donald G.
Lorenzi Matthew V.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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