Novel human nucleic acid molecules and polypeptides encoding...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2436941

The present invention relates to novel human nucleic acid molecules encoding novel human cation channels, and proteins and polypeptides encoded by such nucleic acid molecules. More specifically, the nucleic acid molecules of the invention include novel human genes, e.g., hVR1d.1 and hVR1d.2, that encode proteins or polypeptides that are expressed in spinal cord and brain tissues and display sequence homology and structural homology to the vanilloid and TRP (transient receptor potential) families of cation channel proteins. The proteins and polypeptides of the invention directed to this novel human cation channel may be therapeutically valuable targets for drug delivery in the treatment of human diseases that involve calcium, sodium, potassium or other ionic homeostatic dysfunction, such as central nervous system (CNS) disorders, e.g., degenerative neurological disorders such as Alzheimer's disease or Parkinson's disease, or other disorders such as chronic pain, anxiety and depression, stroke, cardiac disorders, e.g., arrhythmia, diabetes, hypercalcemia, hypocalcemia, hypercalciuria, hypocalciuria, or ion disorders associated with immunological disorders, gastro-intestinal (GI) tract disorders or renal or liver disease.

L'invention concerne de nouvelles molécules d'acide nucléique humain codant pour de nouveaux canaux cationiques humains, et des protéines et des polypeptides codant lesdites molécules d'acide nucléique. Lesdites molécules d'acide nucléique comprennent plus spécifiquement de nouveaux gènes humains, par exemple, hVR1d.1 et hVR1d.2, qui codent pour des protéines ou des polypeptides exprimés dans les tissus de la moelle épinière ou du cerveau, et qui affichent une homologie de séquence et de structure avec les familles vanilloïdes et à potentiel de récepteur transitoire (TPR) de protéines de canaux cationiques. Les protéines et les polypeptides représentant le nouveau canal cationique humain peuvent être des cibles thérapeutiquement valables pour distribuer un médicament permettant de traiter des maladies humaines impliquant le calcium, le sodium, le potassium, ou d'autres dysfonctions homéostatiques ioniques, telles que des troubles du système nerveux central (CNS), par exemple, des troubles neurologiques dégénératifs tels que la maladie d'Alzaheimer ou la maladie de Parkinson, ou d'autres troubles tels que la douleur chronique, l'anxiété et la dépression, les accidents vasculaires cérébraux, les troubles cardiaques, par exemple, l'arrhytmie, les diabètes, l'hypercalcémie, l'hypocalcémie, l'hypercalciurie, l'hypocalciurie, ou des troubles ioniques associés à des troubles immunologiques, des troubles des voies gastro-intestinales (CI) ou à une maladie des reins ou du foie.

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