Novel human proton-gated channels

Details Novel human proton-gated channels Novel human proton-gated channels

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453655

cThe present invention provides a novel human proton-gated ion channel (hASIC1B) and polynucleotides which identify and encode hASIC1B. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding hASIC1B and a method for producing hASIC1B. The invention also provides for use of hASIC1B, and agonists, antibodies or antagonists specifically binding hASIC1B, in the prevention and treatment of diseases associated with expression of hASIC1B. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding of hASIC1B for the treatment of diseases associated with the expression of hASIC1B. The invention also provides diagnostic assays, which utilize the polynucleotides, or fragments or the complements thereof, and antibodies specifically binding hASIC1B.

La présente invention concerne un nouveau canal ionique à porte protonique humain (hASIC1B) et des polynucléotides qui identifient et codent hASIC1B; des vecteurs d'expression issus du génie génétique et des cellules hôtes comprenant les séquences d'acides nucléiques codant hASIC1B ainsi qu'un procédé de production de hASIC1B. Cette invention concerne également l'utilisation de hASIC1B, ainsi que des agonistes, des anticorps ou des antagonistes se liant spécifiquement à hASIC1B, dans la prévention et le traitement des maladies associées à l'expression de hASIC1B. De plus, cette invention porte sur l'utilisation de molécules antisens destinées à des polynucléotides codant hASIC1B pour le traitement de maladies associées à l'expression de hASIC1B. Cette invention concerne également des dosages de diagnostic, dans lesquels on utilise lesdits polynucléotides, ou des fragments ou les compléments de ces derniers, et des anticorps se liant de manière spécifique à hASIC1B.

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