Novel hydantoin derivatives as metalloproteinase inhibitors

Details Novel hydantoin derivatives as metalloproteinase inhibitors Novel hydantoin derivatives as metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61K 31/506 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2590845

The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.

La présente invention concerne des composés représentés par la formule (I): dans laquelle R1, R2, A, A1 et B sont tels que définis dans les spécifications, un processus de préparation de ces composés, des compositions pharmaceutiques contenant ces composés, un processus de préparation de ces compositions pharmaceutiques et leur utilisation en thérapie. Ces composés conviennent comme inhibiteurs NNP.

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