Novel hydantoin derivatives as metalloproteinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4375 (2006.01) A61K 31/4725 (2006.01) A61K 31/506 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2590843

The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.

La présente invention a trait à des composés de formule (I), dans laquelle: R1, R2, A, A1 et B sont tels que définis dans la description; à leurs procédés de préparation; à des compositions pharmaceutiques les contenant; à un procédé pour la préparation des compositions pharmaceutiques; et à leurs utilisation en thérapie. Les composés sont utiles en tant qu'inhibiteurs de MMP.

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