C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 43/02 (2006.01) A61K 31/075 (2006.01) A61K 31/18 (2006.01) A61K 31/21 (2006.01) A61K 31/33 (2006.01) C07C 69/00 (2006.01) C07C 311/00 (2006.01) C07D 295/04 (2006.01) C07D 317/44 (2006.01) C07D 493/00 (2006.01) C07F 7/08 (2006.01)
Patent
CA 2387675
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.
La présente invention porte sur un procédé de fabrication d'un composé enrichi de façon énantiomère et présentant une structure de cycle hydronaphthalène. Le procédé consiste à faire réagir des oxabenzonorbornadiènes avec des nucléophiles en utilisant le rhodium comme catalyseur et en présence d'un ligand de phosphine. Les composés synthétisés peuvent être utilisés dans des préparations pharmaceutiques en vue de traiter une variété de maladies et de troubles.
Fagnou Keith
Lautens Mark
Astrazeneca Ab
Fetherstonhaugh & Co.
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