C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07C 233/05 (2006.01) C07C 233/11 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 235/14 (2006.01) C07D 235/16 (2006.01) C07D 261/04 (2006.01) C07D 263/32 (2006.01) C07D 277/30 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2218345
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as stromelysin and other matrix metalloproteinases, and also inhibit the production of tumor necrosis factor (TNF), and are therefore useful for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula (I).
L'invention porte sur de nouveaux acides hydroxamiques et carboxyliques et leurs dérivés et sur des compositions pharmaceutiques et des méthodes d'utilisation de ces nouveaux composés pour l'inhibition des métalloprotéases matricielles telles que la stromélysine et autres métalloprotéases matricielles, et de la production du facteur de nécrose tumorale (TNF), lesdits composés s'avérant ainsi utiles pour le traitement de l'arthrite et autres maladies inflammatoires associées. Ces nouveaux composés sont représentés par la formule (I).
Decicco Carl Peter
Degrado William F.
Jacobson Irina Cipora
Xue Chu-Biao
Dimock Stratton Llp
Du Pont Pharmaceuticals Company
The Dupont Merck Pharmaceutical Company
LandOfFree
Novel hydroxamic acid and amino-carboxylate compounds as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel hydroxamic acid and amino-carboxylate compounds as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel hydroxamic acid and amino-carboxylate compounds as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1652276