Novel hydroxamic acid derivatives

Details Novel hydroxamic acid derivatives Novel hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61P 43/00 (2006.01) C07C 229/08 (2006.01) C07C 231/02 (2006.01) C07C 233/47 (2006.01) C07C 279/14 (2006.01)

Patent

CA 2373439

Compounds which are useful as drugs because of not only having a high metalloproteinase inhibitory activity but also being capable of remarkably improving the medicinal activities (for example, oral absorbability) and biological activities in vivo; intermediates in the production thereof; and a process for producing the same. Compounds represented by general formula (I) wherein R1, R2, R3, R5, R6, R7 and R8 represent each hydrogen, etc.; and R4 represents alkyl, etc.; or salts thereof are useful as medicinal and/or veterinary compositions, in particular, metalloproteinase inhibitors inhibiting matrix metalloproteinases and/or tumor necrosis factor-.alpha. (TNF- .alpha.) convertase.

L'invention concerne des composés utilisés comme médicaments, ces composés affichant une forte activité inhibitrice de métalloprotéases et étant par ailleurs capables d'améliorer considérablement leur action médicale (par exemple l'absorbabilité orale) et biologique in vivo. Cette invention concerne également des produits intermédiaires servant à l'élaboration de ces composés, ainsi qu'une méthode d'élaboration de ceux-ci. Cette invention concerne en outre des composés représentés par la formule générale suivante (I), dans laquelle: R?1¿, R?2¿, R?3¿, R?5¿, R?6¿, R?7¿ et R?8¿ représentent chacun hydrogène, etc.; R?4¿ désigne alkyle, etc.; ou des sels de ces composés, utilisés dans des compositions médicales et/ou vétérinaires, en particulier comme inhibiteurs de métalloprotéases destinés à inhiber les métalloprotéases matricielles et/ou la TNF-alpha (facteur de nécrose tumorale alpha) convertase.

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