C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61P 15/06 (2006.01)
Patent
CA 2443564
The present invention provides substituted 10, 11-Dihydro-5H-benzo[e]-pyrrolo- [1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or supression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatmet of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals.
La présente invention concerne des composés de 10, 11-dihydro-5H-benzo[e]-pyrrolo-[1,2-a][1,4]diazépine et 9,10-dihydro-4H-3a,5,9-triaza-benzo[f]azulène substitués, ainsi que des procédés et des compositions pharmaceutiques dans lesquels les composés précités sont utilisés pour traiter et/ou prévenir et/ou supprimer des troubles susceptibles d'être guéris ou soulagés par une activité antagoniste de l'ocytocine, y compris pour prévenir et/ou supprimer le travail avant terme, supprimer le travail à terme avant un accouchement par césarienne et pour traiter la dysménhorrée. Les composés de l'invention sont également utilisés pour augmenter les taux de fertilité, les taux de survie, et pour synchroniser les chaleurs chez les animaux d'élevage.
Failli Amedeo Arturo
Sanders William Jennings
Trybulski Eugene John
Smart & Biggar
Wyeth
LandOfFree
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