A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 1/22 (2006.01) C07K 16/06 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01)
Patent
CA 2376335
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The invention concerns Ig fractions having reactivity to IgM, IgG F(ab')2 or DNP hapten and no or little reactivity to non-self antigens, that is Ig fractions which have idiotypic interactions among themselves (connected fraction) or which include natural antibodies reacting with the DNP hapten. Said fractions exhibit a polyreactivity to specific autoantigens.
La présente invention concerne un procédé de préparation de fraction d'Ig à partir d'Immunoglobulines intraveineuses polyvalentes humaines (IgIV) qui seraient plus particulièrement responsables de l'effet immunomodulateur observé au cours des traitements de certaines maladies autoimmunes. L'invention porte sur des fractions d'Ig qui possèdent une réactivité vis-à- vis des IgM, des F(ab')2 d'IgG ou de l'haptène DNP et pas ou peu de réactivité vis-à-vis des antigènes du non-soi, c'est-à-dire des fractions d'Ig qui présentent des interactions de type idiotypique entre elles (fraction connectée) ou qui comprennent des anticorps naturels réagissant avec l'haptène DNP. Ces fractions montrent une polyréactivité vis-à-vis d'autoantigènes donnés.
Bourel Dominique
Bruley-Rosset Martine
Dhainaut Frederic
Lirochon Jacky
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
Robic
LandOfFree
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