Novel imaging agents and methods for the preparation and use...

Details Novel imaging agents and methods for the preparation and use... Novel imaging agents and methods for the preparation and use...

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 51/04 (2006.01) C07H 5/00 (2006.01) C07H 5/02 (2006.01) C07H 5/08 (2006.01) C07H 11/00 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2289585

The nucleoside analog 2'-fluoro-5-methyl-1-.beta.-D-arabinofuranosyluracil (FMAU) has been found to have an especially desirable combination or properties for use as an imaging agent, including in particular limited in vivo catabolism. Methods for the preparation of the [11C]- and [18F]-labeled FMAU and for the use of the labeled material are also provided.

On a découvert que l'analogue de nucléosides, 2'-fluoro-5-méthyl-1- beta -D-arabinofuranosyluracil (FMAU) présente une combinaison de propriétés particulièrement avantageuses, dont un catabolisme in vivo limité, pour une utilisation en tant qu'agent d'imagerie. L'invention porte aussi sur des procédés de préparation dudit FMAU marqué par [<11>C]- et [<18>F] et d'utilisation du matériau marqué.

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