Novel imaging agents for detecting neurological dysfunction

Details Novel imaging agents for detecting neurological dysfunction Novel imaging agents for detecting neurological dysfunction

C - Chemistry, Metallurgy

07

B

C07B 59/00 (2006.01)

Patent

CA 2715390

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding in-dicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease

La présente invention concerne des composés et des procédés permettant de diagnostiquer la maladie dAlzheimer ou une prédisposition à celle-ci chez un mammifère, le procédé consistant à administrer au mammifère une quantité efficace pour un diagnostic un composé marqué, le composé étant choisi dans le groupe constitué par des dérivés marqués de flavones, de coumarines, de carbazoles, de quinolinones, de chromenones, dimidazoles et de triazoles, à laisser le composé se répartir dans le tissu cérébral, et à procéder à une imagerie du tissu cérébral, une augmentation de la fixation du composé au tissu cérébral par comparaison avec un niveau de fixation de contrôle témoin indiquant que le mammifère souffre de la maladie dAlzheimer ou est susceptible de la développer.

Affiliated with

Also associated with

Rating

Novel imaging agents for detecting neurological dysfunction does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel imaging agents for detecting neurological dysfunction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel imaging agents for detecting neurological dysfunction will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2031967