C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4178 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 249/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2498047
Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.szlig. signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
L'invention concerne des composés d'imidazole, des dérivés de ceux-ci, des intermédiaires destinés à leur préparation, des compositions pharmaceutiques contenant ces composés et leur utilisation thérapeutique. Ces composés consistent en des inhibiteurs puissants de la voie de passage de signalisation du facteur de croissance transformant (<= TGF >=)-.beta.. Ces composés sont utiles dans letraitement de divers états pathologiques, notamment, par exemple, les maladies fibrotiques et le cancer.
Blumberg Laura Cook
Munchhof Michael John
Pfizer Products Inc.
Torys Llp
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