Novel imidazole derivative and process for producing the same

Details Novel imidazole derivative and process for producing the same Novel imidazole derivative and process for producing the same

C - Chemistry, Metallurgy

07

D

C07D 233/56 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2178604

A novel imidazole derivative represented by general formula (1) or (2) to be used as a selective muscarine antagonist, wherein R1 represents optionally substitued phenyl or thienyl; R2 represents cyano, hydroxy, carboxy, CONR7R8 (wherein R7 and R8 represent each independently hydrogen or lower alkyl, or R7 and R8 may form together a ring comprising an alkylene chain which may contain a heteroatom) or COOR9 (wherein R9 represents lower alkylene); R3 represents hydrogen or lower alkyl; R4, R5 and R6 represent each independently hydrogen, optionally substitued lower alkyl or cycloalkyl, or R5 and R4 may form a fused benzene ring; R10 represents lower alkyl or optionally substituted aralkyl; m represents an integer of 1 to 6; and Z represents halogen.

Nouveau dérivé de l'imidazole de formule générale (1) ou (2) servant d'antagoniste sélectif de la muscarine, où: R¿1? représente phényle ou thiényle facultativement substitué; R¿1? représente cyano, hydroxy, carboxy, CON R¿7?R¿8? (où R¿7? et R¿8? représentent chacun séparément hydrogène ou alkyle inférieur, ou bien peuvent former ensemble un cycle comprenant une chaîne alkylénique pouvant contenir un hétéroatome) ou COOR¿9? (où R¿9? représente alkylène inférieur); R¿3? représente hydrogène ou alkyle inférieur; R¿4?, R¿5? et R¿6? représentent chacun séparément hydrogène, ou alkyle ou cycloalkyle inférieurs facultativement substitués, ou R¿5?, et R¿4? peuvent former un cycle benzénique fusionné; R¿10? représente alkyle inférieur ou aralkyle facultativement substitué, m représente un entier de 1 à 6; et Z représente halogène.

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