C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/64 (2006.01) A61K 31/33 (2006.01) A61P 25/06 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2708791
Compounds of the formula (I):wherein R1 is optionally substituted imidazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.
L'invention concerne des composés de formule (I), dans laquelle R1 est éventuellement imidazolyl substitué, et R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans le descriptif. L'invention concerne également des procédés d'utilisation de ces composés pour le traitement de maladies médiées par un antagoniste du récepteur P2X3 et/ou P2X2/3, ainsi que des procédésde fabrication desdits composés.
Chen Li
Dillon Michael Patrick
Feng Lichun
Hawley Ronald Charles
Yang Minmin
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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