C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 39/09 (2006.01) A61P 1/04 (2006.01) A61P 15/18 (2006.01)
Patent
CA 2494192
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invetion provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side- chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.
La présente invention concerne des molécules lipopeptidiques immunogènes de synthèse comprenant des épitopes de lymphocytes B et de lymphocytes T auxiliaires colinéaires, et des procédés pour les produire et les utiliser dans le cadre de la production de réponses immunitaires primaires et secondaires, et pour vacciner des animaux contre des antigènes particuliers. L'invention concerne plus particulièrement des lipopeptides hautement solubles, la fraction lipidique étant fixée au groupe de chaîne latérale terminal d'une lysine interne ou d'un analogue à la lysine, de préférence au groupe de chaîne latérale terminal d'un radical diaminoacide interne. De préférence, la lysine interne ou l'analogue à la lysine se trouve entre l'épitope de lymphocyte T auxiliaire et l'épitope de lymphocyte B ou dans l'épitope de lymphocyte T auxiliaire.
Jackson David C.
Zeng Weiguang
Fetherstonhaugh & Co.
The Council Of The Queensland Institute Of Medical Research
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