C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4162 (2006.01) A61K 31/4745 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 37/02 (2006.01) C07D 491/04 (2006.01) C07D 491/052 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2451749
The present invention relates to a novel heterocyclic compound, a pharmaceutical composition comprising said compound, a method and use of said compound for clinical treatment of medical conditions which may benefit from immunomodulation, e.g. rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.
La présente invention concerne un nouveau composé hétérocyclique, une composition pharmaceutique contenant ledit composé, une méthode d'utilisation dudit composé dans le traitement clinique d'états pathologiques pouvant s'améliorer grâce à l'immunomodulation, par exemple la polyarthrite rhumatoïde, la sclérose en plaques, le diabète, l'asthme, une greffe, le lupus érythémateux aigu disséminé et le psoriasis. La présente invention concerne plus particulièrement de nouveaux composés hétérocycliques, constituant des antagonistes CD80 capables d'inhiber les interactions entre CD80 et CD28.
Bjoerk Per Axel
Da Graca Thrige Dorthe
Fex Tomas
Pettersson Lars Olof Goeran
Sorensen Poul
Active Biotech Ab
Gowling Lafleur Henderson Llp
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