Novel immunosuppressive compounds

Details Novel immunosuppressive compounds Novel immunosuppressive compounds

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) C07D 207/48 (2006.01) C07D 265/00 (2006.01) C07D 279/00 (2006.01) C07D 401/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)

Patent

CA 2102178

2102178 9221313 PCTABS00017 This invention relates to anovel class of immuno-suppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamase) activity of the FKBP and inhibit T cell activation. As such, the compounds of this invention can be used as immunosuppressive drugs to prevent or significantly reduce graft rejection in bone marrow and organ transplantations and for use in the treatment of a wide variety of autoimmune diseases in humans and other mammals.

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