C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2694808
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 11 novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-rumor immune responses.
La présente invention porte sur des peptides, des acides nucléiques et des cellules en vue d'une utilisation dans des procédés immunothérapeutiques. En particulier, la présente invention concerne l'immunothérapie du cancer. La présente invention porte en outre sur des épitopes peptidiques de lymphocytes T cytotoxiques (CTL) associés à des tumeurs, individuellement ou en combinaison avec d'autres peptides associés à des tumeurs qui servent de principes pharmaceutiques actifs de compositions de vaccin qui stimulent des réponses immunitaires anti-tumorales. La présente invention porte sur 11 nouvelles séquences peptidiques et leurs variants issus des molécules de HLA classe I et classe II de cellules tumorales humaines qui peuvent être utilisés dans des compositions de vaccin pour déclencher des réponses immunitaires anti-tumeur.
Hilf Norbert
Schoor Oliver
Singh Harpreet
Trautwein Claudia
Walter Steffen
Heenan Blaikie Llp
Immatics Biotechnologies Gmbh
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