Novel impaired wound model

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/37 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2239745

A novel wound healing model and method for studying the pathophysiology of chronic wounds is disclosed. Diabetes is induced in a pig via injection of streptozotocin. Levels of collagenase and elastase are increased in the diabetic pig wounds versus non-diabetic pigs thereby simulating conditions in a chronic wound.

Divulgation d'un modèle nouveau de guérison des blessures et d'une nouvelle méthode d'étude de la pathophysiologie des blessures chroniques. Le diabète est induit chez le porc par injection de streptozotocine. Les concentrations de collagénase et d'élastase sont supérieures dans les blessures des porcs diabétiques par rapport aux porcs non diabétiques, simulant ainsi les conditions d'une blessure chronique.

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