Novel indazole carboxamides and their use

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 31/66 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2571712

The invention is directed to novel indazole carboxamide derivatives. Specifically, the invention is directed to compounds according to Formula (I), wherein R1 and Z are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK~) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

L'invention concerne de nouveaux dérivés d'indazole carboxamide. L'invention concerne plus précisément des composés représentés par la formule générale (I). Dans cette formule générale (I), R1 et Z désignent des éléments décrits ci-dessous. L'invention concerne également des sels de qualité pharmaceutique de ces dérivés. Les composés de l'invention sont des inhibiteurs d'IKK2 et peuvent être utilisés dans le traitement de troubles associés à une activité d'IKK2 (ou bêta IKK), tels que la polyarthrite rhumatoïde, l'asthme et la maladie pulmonaire obstructive chronique (MPOC). Par conséquent, l'invention concerne également des compositions pharmaceutiques comprenant un composé de l'invention. L'invention concerne également des méthodes permettant d'inhiber l'activité d'IKK2 et de traiter des troubles associés, consistant à utiliser un composé de l'invention ou une composition pharmaceutique comprenant un composé de l'invention.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Novel indazole carboxamides and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel indazole carboxamides and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel indazole carboxamides and their use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-2059561

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.