Novel indeno[2,1a]indenes and isoindol[2,1-a]indoles

Details Novel indeno[2,1a]indenes and isoindol[2,1-a]indoles Novel indeno[2,1a]indenes and isoindol[2,1-a]indoles

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2552106

The present invention describes Indeno[2,1a]indene and isoindolo[2,1a]indole derivatives, of the Formula (I), its salts and its stereoisomers, wherein X, R1, R2, R3, R4, R6, R7, R8, R9,R11, R12, R13 and R14 are as described in the specification. The invention also provides a method to prepare compound with formula (I), pharmaceutical composition containing such compounds and method to manufacture a medicament. These compounds are useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardio vascular diseases and cancer.

L'invention concerne des dérivés d'indéno[2,1a]indène et d'isoindolo[2,1a]indole représentés par la formule (I), ainsi que leurs sels et leurs stéréoisomères. X, R¿1?, R¿2?, R¿3?, R¿4?, R¿6?, R¿7?, R¿8?, R¿9?,R¿11?, R¿12?, R¿13? et R¿14? sont conformes à la définition du descriptif. L'invention concerne également un procédé permettant de préparer un composé de formule (I), une composition pharmaceutique contenant de tels composés, et un procédé de préparation d'un médicament. Ces composés peuvent être utilisés pour le traitement de divers troubles du SNC, trouble hématologiques, troubles de l'alimentation, pathologies s'accompagnant de douleurs, pathologies respiratoires, troubles génito-urologiques, pathologies cardio-vasculaires et cancers.

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