Novel indole, indazole and benzimidazole arylamides

Details Novel indole, indazole and benzimidazole arylamides Novel indole, indazole and benzimidazole arylamides

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2761921

Compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

L'invention porte sur des composés représentés par la formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle formule X, Y, Z, R1, R2, R3, R4 et R5 sont tels que définis dans la description. L'invention porte également sur des procédés d'utilisation des composées pour le traitement de maladies associées à P2X3 et/ou comme antagonistes des récepteurs P2X2/3 et sur des procédés de fabrication des composés.

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