C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) A61K 31/404 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 209/10 (2006.01)
Patent
CA 2492669
An indoline compound represented by the general formula (I): (I) (wherein the symbols have the same meanings as in the description) or a pharmaceutically acceptable salt of the compound; and a medicinal composition containing the indoline compound or pharmaceutically acceptable salt. The compound is excellent in ACAT inhibitory activity and lipid peroxidation inhibitory activity and is useful as an ACAT inhibitor or lipid peroxidation inhibitor.
La présente invention concerne un composé d'indoline représenté par la formule générale (I), dans laquelle les symboles ont les mêmes significations que dans la description, ou un sel pharmaceutiquement acceptable dudit composé. L'invention concerne également une composition thérapeutique contenant le composé d'indoline ou un sel pharmaceutiquement acceptable. Ledit composé présente une activité inhibitrice de l'ACAT et une activité inhibitrice de peroxydation lipidique excellentes et est utile en tant qu'inhibiteur de l'ACAT ou qu'inhibiteur de peroxydation lipidique.
Ikai Miho
Kamiya Shouji
Kasai Masayasu
Shirahase Hiroaki
Takahashi Kenji
Fetherstonhaugh & Co.
Kyoto Pharmaceutical Industries Ltd.
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