Novel infectious bursal disease virus and vaccine containing...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/00 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) C07K 14/08 (2006.01) C12N 7/08 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2562136

Separation of a novel infectious bursa fabricii's disease (IBD) virus that cannot be combated with the conventional IBD vaccine; and a novel vaccine effective against the virus. Novel IBD virus TY2 strain was separated and its substrain was obtained. In the TY2 strain, a gene coding for a hypervariable region of VP2 being a principal host defense antigen site of the virus is not cleaved by TaqI and SspI but cleaved by MvaI into about 52 bp and about 422 bp fragments. Thus, the TY2 strain has a genotype different from that of known IBD viral strain. Excellent vaccine against IBD can be obtained from the TY2 strain or a substrain of the virus.

Séparation d'un nouveau virus de la bursite infectieuse (IBD) qui ne peut pas être combattu avec le vaccin contre l'IBD classique ; et nouveau vaccin efficace contre le virus. On a séparé une nouvelle souche TY2 de virus de l'IBD et on a obtenu sa sous-souche. Dans la souche TY2, un gène codant pour une région hypervariable de VP2 étant un site antigène principal de défense contre l'hôte du virus n'est pas clivé par Taql et Sspl mais clivé par Mval en fragments d'environ 52 pb et environ 422 pb. Ainsi, la souche TY2 a un génotype différent de celui de la souche virale de l'IBD connue. On peut obtenir un excellent vaccin contre l'IBD à partir de la souche TY2 ou d'une sous-souche du virus.

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