C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 271/07 (2006.01) A61K 31/496 (2006.01) A61P 29/00 (2006.01) C07D 277/20 (2006.01) C07D 277/34 (2006.01)
Patent
CA 2469395
The invention concerns compounds of general formula (I), wherein: D represents the group Z-HET, -HET being a heterocycle with 5 members such as oxadiazolone (II) or thiazolidine (III) corresponding to formulae (II) and (III) and Z being selected in the group consisting of -(CR¿1?R¿2?)¿n?- and -(CR¿1?=CR¿2?)¿n?; or D represents the group Z=HET, -Z- representing, with the heterocycle, a -Z=HET group of formula (IV) or (V), wherein: -Z= represents -CR¿1?. Said compounds are useful as inhibitors specific of secreted non-pancreatic human phospholipase A¿2? (PLA¿2?-snph) of group II, in particular for treating inflammatory pathologies .
Les composés de formule générale (I) dans laquelle D signifie le groupe Z-HET, -HET étant un hétérocycle à 5 chaînons tel que l'oxadiazolone (II) ou la thiazolidine dione (III) de formules (II et III) et -Z étant choisi dans le groupe constitué par -(CR1R2)n- et -(CR1=CR2)n; ou D signifie le groupe Z=HET, -Z- représentant, avec l'hétérocycle, un groupement -Z=HET de formule (IV) ou (V) dans laquelle -Z= représente -CR1=; sont utiles comme inhibiteurs spécifiques de la phospholipase A2 sécrétée non pancréatique humaine (PLA2- snph) de groupe (II), notamment en thérapie de pathologies inflammatoires.
Godfroid Jean-Jacques
Heymans Francoise
Lamouri Aazdine
Gowling Lafleur Henderson Llp
Yang Ji Chemical Company Ltd.
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