C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 15/29 (2006.01) C12N 15/31 (2006.01) C12N 15/81 (2006.01) C12N 15/82 (2006.01) C12N 15/86 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2296105
The present invention relates to nucleic acid molecules encoding hypusines mutants having the biological activity of an inhibitor of cellular proliferation. The present invention further relates to vectors comprising said nucleic acid molecules, to hosts transformed with said vectors, to methods of producing the polypeptide encoded by the nucleic acid molecule of the invention as well as to the polypeptide itself. In addition, the present invention relates to pharmaceutical and diagnostic compositions comprising one or more of the aforementioned compounds, the methods for synchronizing cell growth and to the use of the vector of the invention in gene therapy.
La présente invention traite de molécules d'acides nucléiques codant des mutants d'hypusines présentant l'activité biologique d'un inhibiteur de prolifération cellulaire. En outre, l'invention concerne des vecteurs renfermant lesdites molécules d'acides nucléiques, des hôtes transformés par lesdits vecteurs, des procédés de fabrication du polypeptide codé par la molécule d'acides nucléiques selon l'invention, ainsi que du polypeptide lui-même. Par ailleurs, la présente invention se rapporte à des compositions pharmaceutiques et de diagnostic contenant un ou plusieurs des composés susmentionnés, aux procédés permettant de synchroniser la croissance cellulaire et à l'utilisation du vecteur selon l'invention en thérapie génique.
Lottspeich Friedrich
Otasek Adam
Young Craig
Goudreau Gage Dubuc
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
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