Novel inhibitors for factor xa

Details Novel inhibitors for factor xa Novel inhibitors for factor xa

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2151044

Novel compounds, their salts and compositions related thereto having activity against mammalian fac- tor Xa are disclosed. The novel compounds include peptide aldehyde analogues having substantial potency and specificity as inhibitors of mammalian factor Xa are further disclosed. The compounds are thought use- ful as inhibitors of factor Xa in vitro or as a therapeu- tic agent for the preparation and treatment of conditions characterized by abnormal thrombosis in mammals. In- termediates useful for the preparation of the novel com- pounds are also disclosed.

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