C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2664296
A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are .beta.-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with .beta.-lactam antibiotics. In particular, the compounds are suitable for use with .beta.-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to .beta.-lactam antibiotics due to the presence of the .beta.-lactamases.
L'invention concerne une classe de composés d'acide 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonique, substitués à la position 2 du noyau bicyclique par un groupe hétérocyclylaminocarbonyle ou un groupe carbocyclylaminocarbonyle, qui sont des inhibiteurs de bêta-lactamase. Ces composés, ainsi que leurs promédicaments et leurs sels pharmaceutiquement acceptables, sont utiles dans le traitement d'infections bactériennes lorsqu'ils sont associés à des antibiotiques bêta-lactame (p. ex. imipenem and ceftazidime) pour lutter contre des micro-organismes résistants aux antibiotiques bêta-lactame, du fait de la présence des bêta-lactamases.
Blizzard Timothy A.
Chen Helen Y.
Chiu Anna
Ha Sookhee
Kim Seongkon
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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