Novel inhibitors of farnesyl-protein transferase

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 241/04 (2006.01) C07D 401/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2355744

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.

L'invention concerne de nouveaux composés et compositions pharmaceutiques qui sont des inhibiteurs de l'enzyme farnesyl protéine transférase. Elle concerne également un procédé servant à inhiber la fonction de Ras et, de ce fait, la croissance anormale de cellules. Ce procédé consiste à administrer le nouveau composé d'aminooxyamide à un système biologique. En particulier, ce procédé inhibe la croissance anormale de cellules chez un mammifère, tel que l'homme.

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