A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 35/14 (2006.01) A61K 38/16 (2006.01) A61P 31/10 (2006.01) C07C 69/76 (2006.01) C07C 229/00 (2006.01)
Patent
CA 2514356
The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become disturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.
La glycation non enzymatique et la réticulation des protéines fait partie du processus de vieillissement, les produits finis de glycation et la réticulation de protéines ayant vécu longtemps augmentant avec l'âge. Le processus est renforcé lors des concentrations élevées de réduction de sucre dans le sang et dans un environnement intracellulaire, par exemple en cas de diabète. L'intégrité structurelle et fonctionnelle des molécules concernées est perturbée par ces modifications et peut avoir des conséquences graves. Les composés de la présente invention peuvent aussi s'utiliser pour inhiber ce processus de glycation non enzymatique de manière à inhiber certains des effets secondaires provoqués par le diabète ou le vieillissement. Les composés sont aussi utiles dans la prévention du vieillissement précoce, de l'altération des protéines dans les aliments et de la décoloration des dents.
Lalezari Iraj
Rahbar Samuel
City Of Hope
Osler Hoskin & Harcourt Llp
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