C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/4035 (2006.01) A61K 31/416 (2006.01) A61K 31/437 (2006.01) A61P 31/14 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2657035
The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a, subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a subject compound, The embodiments provide compounds of the general Formula (III), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Des modes de réalisation de la présente invention concernent des composés de formule générale (I), ainsi que des compositions, comprenant des compositions pharmaceutiques, comportant un composé selon l'invention. Les modes de réalisation concernent composés de formule générale (II), ainsi que des compositions, comprenant des compositions pharmaceutiques, comportant un composé selon l'invention. Les modes de réalisation concernent composés de formule générale (III), ainsi que des compositions, comprenant des compositions pharmaceutiques, comportant un composé selon l'invention. Les modes de réalisation concernent également des procédés de traitement d'infection du virus de l'hépatite C et des procédés de traitement de la fibrose hépatique, les procédés comprenant généralement l'administration à un sujet qui en a besoin d'une quantité efficace d'un composé ou d'une composition selon l'invention.
Andrews Steven W.
Beigelman Leonid
Blatt Lawrence M.
Kennedy April L.
Kercher Timothy
Array Biopharma Inc.
Intermune Inc.
Smart & Biggar
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