C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2492804
The present invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
La présente invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ces derniers. Les composés de formule (I) inhibent l'activité tyrosine kinase de récepteurs du facteur de croissance tels que VEGFR-2 et FGFR-1, ce qui les rend utiles en tant qu'agents anticancéreux. Les composés de formule (I) sont également utiles pour le traitement d'autres maladies associées aux voies de transduction du signal fonctionnant à travers des récepteurs du facteur de croissance.
Barbosa Stephanie
Bhide Rajeev
Cai Zhen-Wei
Lombardo Louis
Qian Ligang
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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